I was wondering if anyone experienced their PMS getting worse after starting treatment for PCOS. My doctor put me on 1000mg of Met and 50mg of Spiro per day. To me it seems like a low dosage, but I am starting to experience really bad PMS. I had PMS before treatment, but my god I'm getting to the point where I'm super-irritable and tired. Along with PCOS, I'm coping with hypothyroidism and being overweight. I am really getting fed up with my situation and plan to take drastic measures to change it. What has anyone else done to combat this problem? Any suggestions are greatly appreciated as I am getting desperate for a cure.