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  1. #1
    Registered User arcticslug's Avatar
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    Default Chinese herb Angelica is an antiandrogen

    I found this research today about how the herb Angelica gigas is a good choice as an antiandrogen for prostate cancer patients.....I thought it was interesting...

    ...possibly also it could help those with PCOS?

    Cancer Res. 2006 Jan 1;66(1):453-63. Links
    Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer.

    Jiang C, Lee HJ, Li GX, Guo J, Malewicz B, Zhao Y, Lee EO, Lee HJ, Lee JH, Kim MS, Kim SH, Lu J.

    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.

    Androgen and androgen receptor (AR)-mediated signaling are crucial for the development of prostate cancer. Identification of novel and naturally occurring phytochemicals that target androgen and AR signaling from Oriental medicinal herbs holds exciting promises for the chemoprevention of this disease. In this article, we report the discovery of strong and long-lasting antiandrogen and AR activities of the ethanol extract of a herbal formula (termed KMKKT) containing Korean Angelica gigas Nakai (AGN) root and nine other Oriental herbs in the androgen-dependent LNCaP human prostate cancer cell model. The functional biomarkers evaluated included a suppression of the expression of prostate-specific antigen (PSA) mRNA and protein (IC50, approximately 7 microg/mL, 48-hour exposure) and an inhibition of androgen-induced cell proliferation through G1 arrest and of the ability of androgen to suppress neuroendocrine differentiation at exposure concentrations that did not cause apoptosis. Through activity-guided fractionation, we identified decursin from AGN as a novel antiandrogen and AR compound with an IC50 of approximately 0.4 microg/mL (1.3 micromol/L, 48-hour exposure) for suppressing PSA expression. Decursin also recapitulated the neuroendocrine differentiation induction and G1 arrest actions of the AGN and KMKKT extracts. Mechanistically, decursin in its neat form or as a component of AGN or KMKKT extracts inhibited androgen-stimulated AR translocation to the nucleus and down-regulated AR protein abundance without affecting the AR mRNA level. The novel antiandrogen and AR activities of decursin and decursin-containing herbal extracts have significant implications for the chemoprevention and treatment of prostate cancer and other androgen-dependent diseases.

  2. #2
    Functional PCOS'er KimberlyMillions's Avatar
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    I'm no doc...but it sounds like it relates closely to us...androgen dependent stood out to me...

  3. #3
    Registered User arcticslug's Avatar
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    what's interesting is Angelica root is commonly prescribed by Chinese doctors for 'women's problems'.

  4. #4
    Registered User August's Avatar
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    Is this this same thing as Dong quai?
    Dong quai ( Angelica sinensis ), also known as Chinese Angelica, has been used for thousands of years in traditional Chinese, Korean, and Japanese medicine. It remains one of the most popular plants in Chinese medicine, and is used primarily for health conditions in women. . . . . .
    -source: http://www.nlm.nih.gov/medlineplus/d...-dongquai.html

    There also seems to be an herb called Angelica in the European herbal tradition but I can't tell that they are related.

  5. #5
    Registered User LeeB's Avatar
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    there are two different forms of angelica. Dang gui is Angelicae Sinensis, which nourishes and moves blood. My recent research also brought to light that peppermint has been found to have androgen lowering properties.

  6. #6
    Registered User agernon86's Avatar
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    I once brought up Dong Quai to my ob, but he didn't know very much about it. I actually came across it while researching Chinese traditional medicines in college. I recently found a tea at the grocery store that contains it. I'm thinking about trying it under supervision from my ob since when I was on bcp I got blood clots.

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