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  1. #1
    Hoping its my Month!!! First-Lady-Love's Avatar
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    Default Provera, Metformin, Clomid?

    my OB/GYN gave me Provera, Metformin and Clomid today. She said Metformin will probably give me an upset stomach. She explained how I should take the drugs. I want to make sure I have this right.

    Take the Provera and on my 5th-9th day of my period I start taking the Clomid. Right? My cycles usually only last 5 days so do I take it on the 5th day of my period or is on the 5th day of the Provera?

    The Metformin, she said take that on a daily basis but start with half a pill first until my body gets use to it then I can start taking a whole pill each day that way i won't be as sick.

    Also I want to know if anyone have success stories on taking these meds? She gave me a supply for 3 months and after that she wants me to come in if I'm not pregnant by then and we will discuss other methods or up the doses of medicine.

    Thanks guys!!! A truck luck of baby dust for all who are ttc. And many blessings to all moms (you guys have the best job in the world!)

  2. #2
    Angels weep... HarleyGirl93's Avatar
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    First - The Provera is meant to bring on menstruation. It's a form of progesterone, which mimics what your body would do after ovulation. The drop-off of progesterone levels is what signals your uterus to start shedding its lining. You would take the Provera start to finish (usually 10days, but your doc may have a diffferent protocol for you) and then wait for menstruation to occur, which usually occurs within 2 weeks of starting Provera. The first day you bleed (more than just spotting) is considered Cycle Day (CD) 1. You would then take Clomid on CD5-9 according to your doc's instruction. If your period is 5 days long usually, you would start Clomid even when you are still bleeding, but I don't think you should still be taking Provera at the same time as when you take Clomid. If you start menstruation before you are done taking Provera, I would call you doc to see if you can stop the Provera early... The progesterone could cause problems with how Clomid works, as high levels of progesterone are not present in the early part of your cycle, pre-Ov. Metformin would be taken throughout your cycle, irrespective of your CD. And yes, starting it slow and building up your dose will help with the potential GI side effects. Good luck and baby dust! HTH Dianna

  3. #3
    Registered User natalie24's Avatar
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    hi i was just going to ask questions about the drugs but that pretty much answers everything apart from what is the metformin actually for? im not at the stage of having the pills etc.i have had blood tests and hsg and seeing specialist in jan to discuss treatment.just wondered x

  4. #4
    Angels weep... HarleyGirl93's Avatar
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    Natalie -Met is a glucose lowering and insulin sensitizing drug, originally used to treat diabetes, but has been proven to be of benefit in alleviating some of the symptoms of PCOS, especially in terms of fertility/anovulation. Too much insulin (or blood glucose) reduces your fertility by causing your ovaries to produce too many androgens, which in turn causes anovulation. Met increases insulin sensitivity, thereby lowering androgens in PCOS patients. It basically improves the ability of whatever insulin you make to escort glucose to the appropriate receptors, which keeps levels of insulin and blood sugar lower. It can also help with weight loss, but it's not a magic bullet for weight loss. You still need diet and exercise. I think Met levels the playing field for putting a PCOS woman on par with a non-PCOS woman in terms of ability to lose weight. HTH Dianna

  5. #5
    Hoping its my Month!!! First-Lady-Love's Avatar
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    Thanks Harley Girl93,
    I got my prescription filled and you were right the Provera is for 10 days. So I will take it for the 10 days. If my period comes before I'm done with the Provera I will call my doctor.

    Thanks for your advice. I hope I'm one of the lucky ones and get pregnant the first few cycles & can carry the baby to term.




    Quote Originally Posted by HarleyGirl93 View Post
    First - The Provera is meant to bring on menstruation. It's a form of progesterone, which mimics what your body would do after ovulation. The drop-off of progesterone levels is what signals your uterus to start shedding its lining. You would take the Provera start to finish (usually 10days, but your doc may have a diffferent protocol for you) and then wait for menstruation to occur, which usually occurs within 2 weeks of starting Provera. The first day you bleed (more than just spotting) is considered Cycle Day (CD) 1. You would then take Clomid on CD5-9 according to your doc's instruction. If your period is 5 days long usually, you would start Clomid even when you are still bleeding, but I don't think you should still be taking Provera at the same time as when you take Clomid. If you start menstruation before you are done taking Provera, I would call you doc to see if you can stop the Provera early... The progesterone could cause problems with how Clomid works, as high levels of progesterone are not present in the early part of your cycle, pre-Ov. Metformin would be taken throughout your cycle, irrespective of your CD. And yes, starting it slow and building up your dose will help with the potential GI side effects. Good luck and baby dust! HTH Dianna
    Me=28 , DH = 29

    Meds: Provera, Metformin 1000mg, Clomid 50mg
    Vitamins: PreCare Conceive Prenatal Vitamins
    (Nov 08 - March 09) NO O

    Provera, Metformin 1000mg, Clomid 100mg (April 2009 - May 2009)O'd in May but BFN
    Vitamins: Vinate One Prenatal Vitamins


    June 2009 - Femara 7.5mg. & Metformin 1000mg
    Vitimans: Vinate One Prenatal Vitamins
    Two mature follies 21mm & 19mm. HCG June 15,2009. Praying for a sticky bun!!!
    HCG blood test scheduled for 6/29/09
    HPT test scheduled for 7/01/09

  6. #6
    Registered User natalie24's Avatar
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    thanks for all the info.it all puts my mind a bit easier.i feel a hell of alot better kind of knowing a bit about what is going to happen.thank you ssooooo much.xxx

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