[SIZE=1Hello! I am rather new to this site, but I was hoping to get some help with this issue! We are trying for #2. I took Femara for the first time this past cycle and to my (delightful) surprise, it worked great. I got a 23mm follicle, had a great lining, and I even O'd on my own! I NEVER ovulate on my own - I am not sure if I ever have before as I have only had a few natural periods in my life (I must take Provera to induce one). I was ECSTATIC that this worked so well for me because Clomid did not work AT ALL - I am definitley a Clomid-resistant cyster! I thought I had to spend thousands of dollars on injectables to get my body to develop mature follicles and ovulate (how we concieved #1), but here I ovulated on a medicine that I took for a few days in the beginning of my cycle and only cost me $10 - that is just amazing to me!!!
Anyway, so here's the problem! I was originally scheduled to do a trigger shot and have an IUI this past cycle, but the day of my u/s, I also had bloodwork done - when I was called later by the nurse, she told me my Dr. was cancelling my IUI this cycle because my Estradiol was a bit low at 110 (as oppossed to the normal 200 per mature follicle). Needless to say I was devastated, and I immediately got online and starting researching E2 levels on Femara and I quickly came to find out that it is completly NORMAL and EXPECTED for E2 to be low on Femara as that is how Femara works - by lowering ones estrogen level. At this point, I was completely infuriated! Through all of my research, I have read over and over that E2 will be signifigantly lower on Femara; that follicles are mature on Femara even though E2 is low; that as long as the follicles are growing, that there is never a reason to cancel a Femara cycle due to low E2; etc...... I have even read that many doctors do not even check their patients E2 levels when they are on a Femara cycle because they already know they are going to be low!!! Now, I realize you can't believe everything you read on the internet, but EVERYTHING I have read states the same thing, and many of the things I read (repeatedly) came from doctors mouths, so it is obviously true!
So, why does every doctor seem to know this but mine??? When I went in the following week for my ovary check after my cancelled IUI, my doctor told me that I have one more dose to try (7.5mg as I took 5mg the first time), and if that does not increase my E2 level, then I can no longer take Femara!!! Are you kidding me???
It seems like every doctor but mine KNOWS that E2 will be low on Femara. I understand that they are the doctor, but that does not mean they know everything - us cysters are very informed patients . MY RE's office does NOT use Femara very often - I had to ask for it as they did not offer it to me. My doctor even said one time in a conversation, "with our limited use of Femara "! They are going to make me stop taking a medicine that works wonderfully for me simply because they do not know enough about it to know that the follicles are still mature on a Femara cycle even though E2 is lower. They will not listen to me when I tell them what I've researched - I feel like I'm talking to a brick wall. How is this fair??? I was able to take a cheap $10 medication and ovulate as oppossed to spending thousands of dollars to O on an injecatble cycle and their going to make me stop taking it if my E2 is not at the normal "non-femara cycle" level on this increased dose. AHHHHHHH!!!!!
I literally just sent in the last check to pay off our over $6,000 balance from the two injectable/IUI cycles we tried last Spring/Summer that were not successful. It feels to me that they don't want Femara to work for me so that I will have to do more injectable cycles giving them a TON more money!!!
I am so sorry for this extremely long rant, but I just had to get this out and I was hoping that any other cysters who have taken Femara might be able to answer some questions. Such as.......
1. What was your E2 level on Femara and how many follicles did you have?
2. Did you concieve with a lower E2 level on Femara?
3. Does your Dr. even check you E2 level on Femara or do they just assume it will be low?
4. If they do check, do they use it as a basis for cancelling a cycle if it is low?
5. Did increasing your dose, correlate to an increase your E2 level (I would think increasing the dose of a medicine that works by lowering estrogen, would just lower it even more???)
Any other comments and experiences are welcome as well! One last quick note regarding my frustration with my RE - I asked if I could just go straight to a combo Femara/low-dose injectable cycle as it gives you the benefit of a few low-dose injections without the TREMENDOUS cost of a full injectable cycle (since there's no more monitoring than in a Femara alone cycle) and they would not let me do it!!! I must first do this 7.5mg dose, but she said even if that does not work, she will not "commit" to the combo cycle. How can they say no? It's extremely successful, it's cost effective, it's MY body, MY treatment, and MY MONEY!!! I need a new doctor, but there are no other RE's in my town!!!
Thank you in advance for any help you can provide. I'm hoping to use your replies when speaking with my doctor next time (not that it will probably