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  1. #1
    Registered User sadpandinha's Avatar
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    Default Spironolactone during pregnancy.

    I just found out 3 weeks ago that I was pregnant after getting 3 BFP. I made an appointment right away and had my first OB appointment last week on November 30th. I had previously thought my lmp was on September 15th which would have put me at around 11 weeks or so. They did not do an ultrasound at that time, but rather scheduled me for a NT Ultrasound for today. Upon starting the ultrasound the lady doing it immediately said that I was much further along than 11 weeks. Turns out I'm actually 24 weeks and 4 days. Total surprise for us! She said the heartbeat, weight and what she could see all looked good. A few things she couldn't check due to the position such as the diaphragm and the face. So my EDD had drastically moved up from June 22nd to March 24th. Apparently I experienced a possible hemorrhage when I thought my lmp was. Making my actual lmp June 15th.

    My concern is that I was taking spironolactone up until 3 weeks ago when I had the positive test. I have been taking 850mg of Metformin and 50mg of Spironolactone twice a day for the past 1 1/2 years. I'm worried what damage could have been caused by the extent of using it all that time without knowing I was pregnant. Last I knew from my endocrinologist, I would need fertility treatments in order to conceive, so we didn't take any precautions and continued life as normal. Now we are pretty worried as we found out we're having a boy and don't know what kind of harm could have been done already. Any suggestions would be greatly appreciated!

  2. #2
    Happy to finally be a Mom redsoxfan's Avatar
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    In all honesty there's not much you can do about it now, but I would definitely get a referral to a perinatologist asap, and also speak to your OB. They should be able to give you a better idea of what to expect. Hopefully everything will turn out fine but I do think you need to see a high risk specialist for at the very least a consult. They can address your concerns about the spiro exposure and give you more specifics about the dosage you were taking and what risks there are to the baby.

    I will say this.. I am really really surprised that your endocrinologist did not have you on birth control when you were taking the spiro. My SIL was taking it and they required her to be on BC and get a blood pregnancy test every month before getting a refill. I guess every doctor is different but they shouldn't have left you with the impression that you couldn't get pregnant on your own just because you have PCOS. That's just irresponsible in my opinion.

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    Registered User Baby4Kay's Avatar
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    all I can say is dont do it.. I have chronic low potassium and magnesium and i have to take a potassium sparring drug( means a drug that keeps potassium in my kidneys. Any way My nephrologist put me on spirolactone before i was preggo. I planned my pregnancy and knew I needed to switch from spiro. Because I have read so many medical journal articles showing evidence the spiro (in mice) changed the sex organs of the fetus. Meaning your baby can have both or a mix up(boy parts but girl secondary part*breast*) All I know is I had to switch to amiloride. Its does the same thing as far as keeping in potassium but is safer than spiro. However i cant breastfeed while on it. But just google spiro while pregnant and you will see what Im talking about. So you should talk to your dr and get off spiro and find an alternative.

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    Happy to finally be a Mom redsoxfan's Avatar
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    Quote Originally Posted by Baby4Kay View Post
    all I can say is dont do it.. I have chronic low potassium and magnesium and i have to take a potassium sparring drug( means a drug that keeps potassium in my kidneys. Any way My nephrologist put me on spirolactone before i was preggo. I planned my pregnancy and knew I needed to switch from spiro. Because I have read so many medical journal articles showing evidence the spiro (in mice) changed the sex organs of the fetus. Meaning your baby can have both or a mix up(boy parts but girl secondary part*breast*) All I know is I had to switch to amiloride. Its does the same thing as far as keeping in potassium but is safer than spiro. However i cant breastfeed while on it. But just google spiro while pregnant and you will see what Im talking about. So you should talk to your dr and get off spiro and find an alternative. I dont think damage could be done in early stages because the gonads are not forming yet. Ask you dr to pull up some medical articles for you to read or research.
    The OP is 24 weeks and was taking it until 3 weeks ago..

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    Registered User Baby4Kay's Avatar
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    Quote Originally Posted by redsoxfan View Post
    In all honesty there's not much you can do about it now, but I would definitely get a referral to a perinatologist asap, and also speak to your OB. They should be able to give you a better idea of what to expect. Hopefully everything will turn out fine but I do think you need to see a high risk specialist for at the very least a consult. They can address your concerns about the spiro exposure and give you more specifics about the dosage you were taking and what risks there are to the baby.

    I will say this.. I am really really surprised that your endocrinologist did not have you on birth control when you were taking the spiro. My SIL was taking it and they required her to be on BC and get a blood pregnancy test every month before getting a refill. I guess every doctor is different but they shouldn't have left you with the impression that you couldn't get pregnant on your own just because you have PCOS. That's just irresponsible in my opinion.

    I agree the dr might have ben a lil relaxed in keeping things up to date. When I was on spiro they made sure I was on BC. My dr told be that I couldnt stay on it when preggo

    However Sanpandinnia- I would talk about getting off though and just monitor the baby. I dont think it does anything else besides affecting the sex organs. If they didnt see anything in the u/s then he is probably fine. I would get a 4d scan as well. Best wishes

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    Registered User alicek's Avatar
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    Talk to your doctor but please don't fret too much. Spironolactone is Category C, which you want to avoid if you can but it's not like you were taking Accutane, where birth defects are an almost certainty and birth control is required. Chances are that all is fine. Congrats on your pregnancy and being further along than you thought!

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    Since you're already so far along, if it had caused any problems, there's a very good chance they would be able to see it on the ultrasound. So if everything looks normal, you're most likely in the clear I'm sure they will do some more scans just to further make sure that all is well.
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    out to lunch stark tjej's Avatar
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    I would talk to your doctor about it right away and find out what tests will need to be done to understand for sure if there have been any effects. My understanding is that it blocks testosterone, so it would be more likely to affect a boy baby.

    Congratulations on your little one and I hope things don't get too complicated figuring out if it has had any affect on your son.

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    Registered User googler123's Avatar
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    Any updates on if everything is okay?

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    Registered User sadpandinha's Avatar
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    I spoke to my OB about this and they didn't seem too concerned. They said that according to the ultrasound everything looked fine and told me not to worry about it.

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    that is good news! Keep us posted.
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    Registered User giantsfan's Avatar
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    I came across your post on this forum while trying to find other woman who have gone through what I am going though now.
    I found out I was four weeks pregnant last week and had taken Spiro during my 1st week (had not taken it in months prior at all). I stopped taking it because I felt sick off of it, but looking back it may have also been morning sickness kicking in.
    Anyway, I am really concerned about what I have done, and wondering if I should continue the pregnancy or terminate.

    Wondering if you could let me know how the baby turned out.

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    out to lunch stark tjej's Avatar
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    FWIW, the first week of pregnancy you should be just fine. Spiro affects testosterone and sex development, and that really isn't going on at 1 week. IF something really bad happened that early, the baby would likely not make it on its own.

    I am sure a doctor could talk to you about it and reassure you.

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    Registered User sadpandinha's Avatar
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    So far I've had 3 different 3d/4d ultrasounds and nothing has showed up out of the ordinary and I keep getting reassured that he looks perfect and normal! So I hope they are right. I was told by my OB and endocrinologist that the dosage I was on was not high enough to probably cause any damage, but of course I won't know for sure.
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    Default Im really worry :( :( help please

    im in 16 weeks on my pregnancy. Right after i got marry i wen to doctor trying to find help for the acne .. between the wedding and adapting to a new life my hormones were a little out of control he prescribed me minocycline 50 mg twice a day plus spironolactone 100 mg once a day .. he never mentioned that i should take it while pregnancy or if i was trying to get pregnant . i wasn't trying but i wasn't in birth control pills either since my hormones were crazy already i didn't want to make it worst using a birth control pills, also my husband and i didn't care if it happen we knew that it was going to happen eventually so we weren't using any protection . 5 days after i start taking the pills i noticed that i was late in my period for one day i stopped taking the pills just for precaution, took a pregnancy test and it came back positive . i only took 5 pill of spironolactone and 9 for minocycline for what the doctor said i might conceived any time between December 4 and December 10 i start taking the pills in december 19 and stopped it by the 26 approximately . now my OB told me about serious birth defect that can be cause for taking this pills im so extremely worry please any one can explain me more about it .. my doctor said that we need to wait and later we will able to see but im in love with this baby already and i dunno what can happen ... help me please ... since my doctor told me that im a total mess .. crying everyday .. because i know that if something will be wrong with my little one will my fault ... help please

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