Can anyone explain the coorelation between E2 and femara. It is my understanding that for a mature follie there needs to be about a 200 on the E2, but since femara is an estrogen blocker, aren't the numbers lower then? This is my first cycle on femara and they never checked my E2 on clomid, why do they on Femara? I had a cyst at my baseline u/s and on CD3 my E2 was higher than on CD10 with the cyst gone. I don't know what the numbers were, just that it's a little lower. Could it be because the cyst was still producing estrogen? I am going in again next Monday for another u/s and bloodwork. The nurse said something about taking a few more days of the femara, but won't that overstim? Shouldn't I just wait for another u/s? I O on my own and with clomid, is there some way femara could stop me from Oing? I am so confused at this point.