Results 1 to 11 of 11
  1. #1
    Registered User jc-'s Avatar
    Join Date
    Nov 2011
    Posts
    256
    Thanks
    72
    Thanked 60 Times in 55 Posts

    Default Femara and low estradiol

    Can anyone explain the coorelation between E2 and femara. It is my understanding that for a mature follie there needs to be about a 200 on the E2, but since femara is an estrogen blocker, aren't the numbers lower then? This is my first cycle on femara and they never checked my E2 on clomid, why do they on Femara? I had a cyst at my baseline u/s and on CD3 my E2 was higher than on CD10 with the cyst gone. I don't know what the numbers were, just that it's a little lower. Could it be because the cyst was still producing estrogen? I am going in again next Monday for another u/s and bloodwork. The nurse said something about taking a few more days of the femara, but won't that overstim? Shouldn't I just wait for another u/s? I O on my own and with clomid, is there some way femara could stop me from Oing? I am so confused at this point.
    Me: (30) Fiance: (34) Hidden Content Together for 8 years
    TTC since 2012- 3 angel babies
    -baby girl April 24th, 2013
    Surprise BFP New Years Day- not trying, but oh so happy!
    EDD: Sept. 10, 2014---- Team Green

    Hidden Content


  2. #2
    Such stuff as dreams... Katie_Lucey's Avatar
    Join Date
    Jun 2009
    Location
    PA to CO to NC
    Posts
    11,714
    Thanks
    2,241
    Thanked 2,942 Times in 2,269 Posts

    Default

    It was lower bc the cyst was gone and the cyst was producing estrogen. It will need to be 200-600 per mature follicle at ovulation. My doc doesn't check e2 on any meds except with IVF. You should do 5 days on femara then stop.
    Katie (32) Patrick ( 33)
    M/C: 02/01*10/10*03/12*04/12
    August 2011- Connor was born
    February 2013- Jackson was born
    We are overwhelmingly blessed!
    Hidden Content

  3. #3
    Such stuff as dreams... Katie_Lucey's Avatar
    Join Date
    Jun 2009
    Location
    PA to CO to NC
    Posts
    11,714
    Thanks
    2,241
    Thanked 2,942 Times in 2,269 Posts

    Default

    Femara is not like injects where you will overstim if you take it longer. It doesn't actually block estrogen production it blocks estrogen receptors so your body doesn't think you are producing estrogen and produces more.
    Katie (32) Patrick ( 33)
    M/C: 02/01*10/10*03/12*04/12
    August 2011- Connor was born
    February 2013- Jackson was born
    We are overwhelmingly blessed!
    Hidden Content

  4. #4
    Feet on the Ground defygravity's Avatar
    Join Date
    Jun 2008
    Location
    Atlanta Metro
    Posts
    8,016
    Thanks
    2,001
    Thanked 2,195 Times in 1,757 Posts

    Default

    The only bloodwork my RE does with Femara is a blood pregnancy test between rounds to be absolutely sure there's no pregnancy. I've never had E2 levels checked, although I'm only on my second round of Femara now.
    Justine (33) Hidden Content DH (34)
    Hidden Content
    Hidden Content
    "In truth, the art of baby making is not an art at all, nor even a science,
    but completely governed by the absolute nonsensical unknown that is at the heart of all existence here on earth and elsewhere." - Hidden Content Hidden Content

  5. #5
    Registered User jc-'s Avatar
    Join Date
    Nov 2011
    Posts
    256
    Thanks
    72
    Thanked 60 Times in 55 Posts

    Default

    Okay so my RE called in a script for 4 more pills of femara. 2.5mg from yesterday to Sunday. I picked them up, but didn't take it last night. Has anyone ever taken femara twice in the same cycle? It is a lower dose, but I think I should wait and see what the first round of 5mg does before adding more. I wish I could get some better responses from the nurses. It would be even more nice to talk to my RE, so he can explain things to me instead of giving me the doctors orders with no explaination.
    Me: (30) Fiance: (34) Hidden Content Together for 8 years
    TTC since 2012- 3 angel babies
    -baby girl April 24th, 2013
    Surprise BFP New Years Day- not trying, but oh so happy!
    EDD: Sept. 10, 2014---- Team Green

    Hidden Content


  6. #6
    Such stuff as dreams... Katie_Lucey's Avatar
    Join Date
    Jun 2009
    Location
    PA to CO to NC
    Posts
    11,714
    Thanks
    2,241
    Thanked 2,942 Times in 2,269 Posts

    Default

    Personally I've found that taking more than 5 days has been very bad on my lining. I have a friend who HAD to take 10 days of the highest doses to get 1 follie but she was VERY med resistant. Did you O on clomid? If you did then I would stick with teh 5 days. Once you take it you have to give your body a chance to work with the estrogen it's producing and cycle. If you keep taking femara it's just going to delay your cycle more.

    When is your next u/s? cd12? I assume they want to check things out about cd12/13 to see if you have any follies in there?If you have been on femara this whole time you probably won't. It takes about a 5-7days after you stop the meds for your body to make the hormones to produce mature follies.
    Katie (32) Patrick ( 33)
    M/C: 02/01*10/10*03/12*04/12
    August 2011- Connor was born
    February 2013- Jackson was born
    We are overwhelmingly blessed!
    Hidden Content

  7. The Following User Says Thank You to Katie_Lucey For This Useful Post:

    jc- (06-07-2012)

  8. #7
    Registered User jc-'s Avatar
    Join Date
    Nov 2011
    Posts
    256
    Thanks
    72
    Thanked 60 Times in 55 Posts

    Default

    Quote Originally Posted by Katie_Lucey View Post
    Personally I've found that taking more than 5 days has been very bad on my lining. I have a friend who HAD to take 10 days of the highest doses to get 1 follie but she was VERY med resistant. Did you O on clomid? If you did then I would stick with teh 5 days. Once you take it you have to give your body a chance to work with the estrogen it's producing and cycle. If you keep taking femara it's just going to delay your cycle more.

    When is your next u/s? cd12? I assume they want to check things out about cd12/13 to see if you have any follies in there?If you have been on femara this whole time you probably won't. It takes about a 5-7days after you stop the meds for your body to make the hormones to produce mature follies.
    I don't think I'm med resistant. I O on my own and on clomid. They instructed me to take the 2.5 for CD 11-14 and then come in on CD16 for another u/s. I took 5mg on CD3-7 already and went in on CD10 for the last u/s. If we don't start producing hormones until 5-7 days after stopping meds, I would have only been in 3 days after stopping and things wouldn't be underway really. What's the point of adding more and delaying things? Is another 4 days of 2.5 really supposed to help?
    Me: (30) Fiance: (34) Hidden Content Together for 8 years
    TTC since 2012- 3 angel babies
    -baby girl April 24th, 2013
    Surprise BFP New Years Day- not trying, but oh so happy!
    EDD: Sept. 10, 2014---- Team Green

    Hidden Content


  9. #8
    Such stuff as dreams... Katie_Lucey's Avatar
    Join Date
    Jun 2009
    Location
    PA to CO to NC
    Posts
    11,714
    Thanks
    2,241
    Thanked 2,942 Times in 2,269 Posts

    Default

    I have never heard of a doctor adding another round of meds unless you go in cd12/14/16/18/20+ and do u/s and labwork and you are not responding at ALL- then I have seen them add more meds at that point. Yeah if you toko the meds from 3-7 I woulnd't expect to see notable follies until cd12 if you stop the meds at cd7. Did they give you a reason for doing more? It's really odd if you were responding to 5 days of clomid. Femara is usually the same protocol- 5 days of meds then u/s about 5 days after meds stop.
    Katie (32) Patrick ( 33)
    M/C: 02/01*10/10*03/12*04/12
    August 2011- Connor was born
    February 2013- Jackson was born
    We are overwhelmingly blessed!
    Hidden Content

  10. #9
    Registered User jc-'s Avatar
    Join Date
    Nov 2011
    Posts
    256
    Thanks
    72
    Thanked 60 Times in 55 Posts

    Default

    The only thing they mentioned was my E2 was lower than at my baseline. That was obviously from the cyst though. I thought the CD10 u/s was to make sure the cyst took care of itself and then go in again when I normally do on CD 14-16. Not prescribe me more and delay things. I guess that's what I get for thinking. Thanks so much for your replies too. You have taught me so much!
    Me: (30) Fiance: (34) Hidden Content Together for 8 years
    TTC since 2012- 3 angel babies
    -baby girl April 24th, 2013
    Surprise BFP New Years Day- not trying, but oh so happy!
    EDD: Sept. 10, 2014---- Team Green

    Hidden Content


  11. #10
    Such stuff as dreams... Katie_Lucey's Avatar
    Join Date
    Jun 2009
    Location
    PA to CO to NC
    Posts
    11,714
    Thanks
    2,241
    Thanked 2,942 Times in 2,269 Posts

    Default

    I agree with your thinking completely. THe cd 10 was to see the cyst clear up- the e2 dropped bc the cyst was gone and no longer producing hormones. Now it's time for the hormones to kick in and make some follicles you can see around cd12-15. If you stay on the femara it's just going to push your cycle out further. My friend who did 10 days 10 and 12.5 mgs to get one follie still woulnd't get an u/s to see mature follicles until a week after she stopped so she took it 3-12 and had mature follicles around cd 18 and O'd around day 19/20.
    Katie (32) Patrick ( 33)
    M/C: 02/01*10/10*03/12*04/12
    August 2011- Connor was born
    February 2013- Jackson was born
    We are overwhelmingly blessed!
    Hidden Content

  12. The Following User Says Thank You to Katie_Lucey For This Useful Post:

    jc- (06-07-2012)

  13. #11
    Registered User ladydamia's Avatar
    Join Date
    Jan 2012
    Location
    North Dakota
    Posts
    19
    Thanks
    0
    Thanked 0 Times in 0 Posts

    Default

    My e2 was low at my mid cycle us after taking femara. I ended up needing Estrace to help, because my lining was thin. My e2 was 35. Still in the 2ww.
    Me:29, Him: 25
    DS: 09/2010
    Me: PCOS, anovulatory. 1500mg Metformin/daily... Still no ovulation. Hsg showed 2 blocked tubes, cleared via laproscopy 7/2012, here We go again!
    Him: Great count, low morphology/motility.
    TTC#2!

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •