[coverattach=1]What is acanthosis nigricans?
Acanthosis nigricans (AN) is a skin disorder characterised by darkening (hyperpigmentation) and thickening (hyperkeratosis) of the skin, occurring mainly in the folds of the skin in the armpit (axilla), groin and back of the neck.
Acanthosis nigricans is not a skin disease per se but a cutaneous sign of an underlying condition or disease.
There are two important types of acanthosis: benign and malignant. Although classically described as a sign of internal malignancy, this is very rare. Benign types, sometimes described as ‘pseudoacanthosis nigricans’ are much more common. [coverattach=2]
What is the treatment for acanthosis nigricans?
The primary aim of treatment is to correct the underlying disease process. Often correcting the underlying cause results in resolution of the lesions.
- Correct hyperinsulinaemia through diet and medication
- Lose weight with obesity-associated AN
- Excise or treat underlying tumour
- Stop offending medicines in drug-induced AN
- In hereditary AN, lesions tend to enlarge gradually before stabilising and/or regressing on their own.
[coverattach=3]There is no specific treatment for AN. Treatments considered are used primarily to improve cosmetic appearance and include topical retinoids, dermabrasion and laser therapy.
source: http://dermnetnz.org/systemic/acanthosis-nigricans.html
DOWNLOAD PDF: http://dermnetnz.org/systemic/pdf/ac...-dermnetnz.pdf



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