Role of insulin in the hyperandrogenemia of lean women with polycystic ovary syndrome and normal insulin sensitivity.
Baillargeon JP, Carpentier A.
Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Sherbrooke, Quebec, Canada. jp.baillargeon@usherbrooke.ca
OBJECTIVE:To determine the effect of reducing insulin secretion on hyperandrogenemia in lean normoinsulinemic women with polycystic ovary syndrome (PCOS) and normal metabolic insulin sensitivity.
CONCLUSION(S): In women with typical PCOS and normal insulin levels and metabolic insulin sensitivity, reducing insulin secretion significantly decreased androgen and increased SHBG levels. These results suggest that insulin contributes to hyperandrogenemia even in PCOS women with normal metabolic insulin sensitivity, which might be due to increased sensitivity of their androgenic insulin pathway.
DESIGN: Transversal assessment at baseline and prospective follow-up of lean PCOS group after 8 days of diazoxide, which reduces insulin secretion, and 1 month of leuprolide, which suppresses LH.
SETTING: Clinical research center of an academic hospital.
PATIENT(S): Nine lean women (body mass index <or=25 kg/m(2)) with PCOS and normal insulin levels, as well as 17 lean healthy women.
INTERVENTION(S): Lean PCOS women were reassessed after 8 days of diazoxide and after 1 month of leuprolide, which suppresses LH. MAIN
OUTCOME MEASURE(S): Androgen levels and insulin-stimulated glucose disposal (metabolic insulin sensitivity), determined by euglycemic-hyperinsulinemic clamp (M-value).
RESULT(S): Mean M-value of lean PCOS women (48.5 micromol/kg.min) was similar to lean control subjects (52.9 micromol/kg.min). They also had comparable anthropometric measures, lipids, fibrinogen, and plasminogen activator inhibitor 1. The LH did not change significantly after diazoxide, but was almost suppressed after leuprolide in the PCOS group. Androstenedione decreased significantly after diazoxide and even more after leuprolide. However, free T significantly decreased only after diazoxide in lean PCOS women. Diazoxide also increased SHBG significantly in this group.
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Hey, SoulCysters! Need to eat more veggies, but can't find recipes??
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This is hard to understand, and I'm in Nursing school, but I'm glad to see research being done on this group of people with PCOS.
There's always been research done on 'lean pcos' despite the comments to the contrary. Regular checks of PubMed from time to time, would keep any Thin Cyster 'in the loop'. Again, the correct search terms at PubMed would be: lean pcos
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Hey, SoulCysters! Need to eat more veggies, but can't find recipes??
To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.
There's always been research done on 'lean pcos' despite the comments to the contrary. Regular checks of PubMed from time to time, would keep any Thin Cyster 'in the loop'. Again, the correct search terms at PubMed would be: lean pcos
Thanks for the article, it seems like there isn't a lot of research done on people who are thin with pcos.
__________________ Me 35 DH 40
Dx PCOS 11/06
6 cycles clomid all BFN
3 IUI's w/clomid BFN
IVF #1 BFN 11/07
FET #1 BFN 1/08
FET #2 BFN 4/08
2 Frozen Embryos left from IVF #1 but onto new RE
IVF #2 7/08 BFP after 2 day transfer 7/21, 20 embryos on ice
beta 1 7/21=130
beta 2 7/23=228
Its Boy/Girl twins!!!!!
Justin and Morgan arrived on 3/4/09! To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.
I AM SO GLAD I came to this site...and so relieved that someone has done this research. I had myself tested for insulin resistance since finding out I have PCOS, and it seems I have normal levels, but I've since completely changed my diet anyway (no sugar, bread, ALL low glycemic index foods) and I've been wondering whether it will make any difference on my hair growth, lack of period, etc. Now I know it will!:
"In women with typical PCOS and normal insulin levels and metabolic insulin sensitivity, reducing insulin secretion significantly decreased androgen and increased SHBG levels. These results suggest that insulin contributes to hyperandrogenemia even in PCOS women with normal metabolic insulin sensitivity, which might be due to increased sensitivity of their androgenic insulin pathway."
I am a reformed 'big' girl. I had a gastric bypass and everyone wondered why I didn't just have normal fertility afterward. Now i am with you all and have the problem described here. Thanks for posting the article
well it might be helpful for some cysters but not me though.
I have been on low glycemic diet with no improvement.I even eat buckewheat everyday.
I think there is more in to it than just insulin.
however I feel much better,less tired and sleepy and I dont get any headaches or crave for sweets.
__________________ -------------------------------- 26-Engaged to my DBF To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.
Diagnosed in March 09
---------------------- symptoms: Acne mild Hirsutism recent hairloss Iregular menses
---------------- Meds I'm currently On: Accutane Vitex Npc sage tea Licorice tea Ultimate goal: To find a natural solution for my pcos symptoms To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.
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As english is not my first language, I'm struggling with this one
So what does this exactly mean: "However, free T significantly decreased only after diazoxide in lean PCOS women."
I'm "lean" and have pcos. My insulin levels are normal, but free T in slightly elevated. Even though my doctor (who is specialized in pcos) never suggested I change my diet, I did. I've cut out sugar, wheat, all white flours, caffeine, and lately dairy. I've noticed big improvements, but I'm not cured yet
Interesting to see if my next lab results show improvement as well!
Study: Androgens in Thin Cysters with and without IR 
