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Old 11-03-2008, 09:09 PM   #1 (permalink)
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Default Thin lining

Hi, I'm already passed the 2 year mark of ttc and depressed. wondering if anyone can help... I have tried Clomid twice, 3 IUI, 2 IVF and 2 cancelled frozen IVFs. My RE recommended that I see a gyne specialist for a hysteroscopy. So I went to see him and he wanted to try a bunch of other tests in addition to the hysteroscopy. While I waited for the test results, he recommended trying Clomid at a higher dosage. And I actually responded though my lining was still very thin around 4 (a problem I had with IUI and IVF). I've tried Estrace in the past but that didn't help. Anyone have any suggestions for me?

another question I have is whether you always have PCOS or if it can come and go? My RE didn't diagnose me with PCOS but the gyne specialist did. I'm 5'5" 140. irregular periods, horrible hair issues, acne, polycystic ovaries.

help me!!
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Old 11-03-2008, 10:08 PM   #2 (permalink)
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(((Hugs))) I'm sorry!

I've never TTC, but at one point I had low progesterone that lead to bleeding in the latter half of my cycle. My GYN suggested that I may need to use some sort of progesterone supplement. I wound up back on BCPs due to prolonged bleeding and a huge cyst and have been on them since. . .again I'm not TTC.

Perhaps progesterone supplementation would help boost your lining? Just food for thought.

Also, maybe someone in the TTC forum will have better advice.

Sending you good vibes!
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Old 11-03-2008, 11:24 PM   #3 (permalink)
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First off, no, PCOS can't come and go, but hormonal fluctuations can of course occur. I'm really sorry you've had such a hard time. One question I have is why do they keep putting you on Clomid with a thin lining??? Clomid is anti-estrogenic and has a very long lasting effect on the lining, and the more you use the worse your lining can get. I have struggled with a thin lining, but my max was 6.5 mm (which is what got me pg this time), and my RE was never concerned about it, b/c it had the triple layer and always got to 6 by the time of ovulation/egg retrieval.

I have heard some have success with intravaginal Viagra for lining problems in addition to estrogen. Also, vaginal estrogen has been shown to help more than oral estrace or the patch, creating higher levels locally where they are needed.

All-in-all, though, I would say stop the clomid, as it is most likely only making things worse. Ask your doc about vaginal Viagra and/or estrogen for plumping things up. Is your lining formin the 3 layers? Have you had an endometrial biopsy?
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Old 11-04-2008, 12:53 PM   #4 (permalink)
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I'll try to make a long story short as to why I'm back on Clomid... my first RE did a hysteroscopy after the 2nd failed IVF. He thought maybe something was wrong with my uterus. He only found a few polyps. Then we tried 2 frozen IVFs that had to be cancelled because my lining wasn't thickening but my estrogen level was rising. So my RE sent me to a gyne specialist for a repeat hysteroscopy. The gyne put me on Clomid so that we could "try" while simultaneously having some special ultrasounds, HSG and a hysteroscopy.

I was hoping that maybe I'd get pregnant on Clomid instead of going back to IVF. sounds like that's a long-shot.
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Old 11-04-2008, 05:44 PM   #5 (permalink)
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Would your doctor prescribe Femara? It works similarly to Clomid, but has a very short half-life, so has no lasting effects on the lining. I've been to 2 docs who do prescribe it and one who doesn't. I would never say you have to go back to IVF -- but give something other than Clomid a try, or the lining issue may never get better!

Best of luck to you.
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Old 11-06-2008, 08:13 PM   #6 (permalink)
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I haven't heard of Femara. Is there a particular reason why your one doctor would not prescribe it? What are it's side affects? thank you for all of your help. I really appreciate it!
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Old 11-06-2008, 11:08 PM   #7 (permalink)
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Femara is a drug that was initially designed to treat breast cancer, but it was found that when used in a similar way to clomid (most prescribe it CD3-7 or 5-9), it works in a similar way but with a very short half-life it is gone from your system before ovulation (thus the lack of harm to your lining). It has essentially no side effects for most women (unlike Clomid that can do the crazy mood swings, hot flashes, etc). And for a lot of cysters it works to stimulate ovulation when Clomid doesn't work.

The reason some docs still don't prescribe it is b/c there was a study done several years ago that showed a link with some minor birth defects. Unfortunately, it was a very poorly designed study, and several large studies have been done since then that disprove the original study, but some docs are still afraid to prescribe it. When used correctly, it is gone from your system before you even ovulate, much less before any implantation can occur. Of course if you take it WHEN you are pg, it could cause defects (as can clomid).
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After soy, Femara, Follistim, an ectopic pregnancy, and IVF, FINALLY BFP 8/08 -- twins -- but lost baby B at 7 weeks
Preterm labor at 25 weeks... baby boy is here safely at 36w3d!


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Old 11-10-2008, 04:15 PM   #8 (permalink)
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I used red raspberry leaf to increase mine
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