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Old 07-27-2006, 09:46 PM   #1 (permalink)
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Question why/how does met work for non-IR cysters??

I can't work this one out. (I am IR by the way - so this is a curiosity question more than anything else).

My repro specialist told me he pre-treats every women (regardless of whether they are IR, or even have PCOS) with Met before IVF, since it is supposed to improve their egg quality. I did some research elsewhere and found that normal, stable blood glucose levels lead to better egg quality.

BUT - then why/how does Met work in getting non-IR cysters to ovulate???

Does better egg quality also mean the egg is more likely to release from the ovary?? That is about the best educated guess I can think of....

Anyone else know? Anyone asked their doc?
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Old 07-28-2006, 12:19 AM   #2 (permalink)
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I have no idea but my guess is that if it improves egg quality then it must make O stronger. I dont know if I am IR or not but my doc put me on it and it has helped. I O'ed on monday and "ouch" but I am guessing that is why. Hope someone has a better answer. Now I want to know.
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Old 07-31-2006, 12:37 AM   #3 (permalink)
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***bump***

Anyone know?
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dx mar 06 PCOS/IR - 2000mg Metformin, multivitamin, B12, chromium, fish oil

dx may 06 male factor - Y chromosome microdeletion and chronic abacterial prostatitis

dx may 07 depression (but suffered throughout my teens) - 50mg Zoloft

tried Clomid (100mg) last year
now waiting for the results of DH's prostatitis treatment ....
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Old 07-31-2006, 12:52 AM   #4 (permalink)
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I'm not sure anyone really knows exactly how/why Met works. But, better egg quality means more likely to fertilize and implant, I think.
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Old 07-31-2006, 04:11 PM   #5 (permalink)
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My RE said it will straighten out my hormones - high testosterone and high LH, but I also am not insulin resisitant as far as I know. But since it can help us to O sooner it would give better egg quality and also our lining wouldn't be too thick or old (point in case, my last cycle started Feb 1 and ended June 29 - not so good for eggie or lining). But, it's working for me, I'm losing a bit of weight (I am considered a thinner cyster, but am still at the top of my healthy weight) and it got me to O on CD25, rather than CD 125ish....!!!
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Old 07-31-2006, 07:42 PM   #6 (permalink)
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There are several reasons why it can help non_IR women.

One, is that the blood tests for IR are really inaccurate and many women who show No-IR really are.

The other reason is that it's affect on insulin (even in Non-IR people), causes other major hormones (like male hormones etc) to all regulate.

IF you check out the FAQ thread at the top of this forum, there is a ton of studies and info too on non-IR women and the effects of metformin.

FAQ About Metformin

FAQ #3 is "What If I'm not IR or obese. Can I still take Met?". There is lots of info there.

Hope it helps.
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