Dong Quai bothers my stomach a little if I take it on an empty stomach so I always eat with it now. Aside from that I have not noticed any side effects. I take it with Vitex, Kelp, Siberian Ginseng, Vit. E, Multivitamin, Hawthorn, EPO, Milk Thistle and Wild Yam. I have one 7 year old DD thanks to this regimen and am now trying to heal my repro system again.
There are varying opinions on when to take it during your cycle although everyone agrees NOT to use it during your period as it can make bleeding worse. I personally use from O to AF. If there is no O then I start it sometime after day 14.

Sheri